Bis-Mal-Lysine-PEG4-TFP ester

Base Information

Chemical Name:Bis-Mal-Lysine-PEG4-TFP ester
CAS No.:1426164-53-5
Molecular Formula:C₃₇H₄₅F₄N₅O₁₃
Molecular Weight:843.784
Hs Code.:

Synonyms:bis-maleimide-lysine-PEG₄-TFP

Suppliers and Price of Bis-Mal-Lysine-PEG4-TFP ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bis-Mal-Lysine-PEG4-TFPester
1mg
$ 45.00

BroadPharm
Bis-Mal-Lysine-PEG4-TFPester 98%
100 MG
$ 360.00

BroadPharm
Bis-Mal-Lysine-PEG4-TFPester 98%
1 G
$ 1650.00

BroadPharm
Bis-Mal-Lysine-PEG4-TFPester 98%
500 MG
$ 1100.00

Apolloscientific
Bis-Mal-Lysine-PEG4-TFP ester
100mg
$ 701.00

Total 11 raw suppliers

Chemical Property of Bis-Mal-Lysine-PEG4-TFP ester

Chemical Property:

Boiling Point:1012.1±65.0 °C(Predicted)
PKA:14.12±0.46(Predicted)
Density:1.364±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Bis-Mal-Lysine-PEG4-TFPester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Bis-Mal-Lysine-PEG4-TFP ester contains two malimide end groups which can react with thiol groups from pH 6.5 to 7.5 to form thiolester bonds. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG linker increases the compound's water solubility in aqueous environments.

Technology Process of Bis-Mal-Lysine-PEG4-TFP ester

There total 6 articles about Bis-Mal-Lysine-PEG4-TFP ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769-39-1,85303-67-9
2,3,5,6-tetraflourophenol

: 1426164-52-4
MAL-Lys(MAL)-dPEG₄-acid

: 1426164-53-5
bis-maleimide-lysine-PEG₄-TFP

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 10.5 - 36.8 ℃; Inert atmosphere;

Reference yield:

: 405-39-0
N,N'-di-[(phenylmethoxy)carbonyl]-L-lysine

: 1426164-53-5
bis-maleimide-lysine-PEG₄-TFP

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; tert-butyl methyl ether / 0 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 5 - 55 °C

3: 2,6-dimethylpyridine / dichloromethane / 35 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10.5 - 36.8 °C / Inert atmosphere

With 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether;

Reference yield:

: 1426164-49-9
tert-butyl (S)-9-(((benzyloxy)carbonyl)amino)-3,10-dioxo-1-phenyl-2,14,17,20,23-pentaoxa-4,11-diazahexacosan-26-oate

: 1426164-53-5
bis-maleimide-lysine-PEG₄-TFP

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 5 - 55 °C

2: 2,6-dimethylpyridine / dichloromethane / 35 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 10.5 - 36.8 °C / Inert atmosphere

With 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane;