1426164-52-4 Usage
Description
Bis-Mal-Lysine-PEG4-acid is a PEG (polyethylene glycol) linker featuring two maleimide groups that can react with thiols within a pH range of 6.5 to 7.5, forming a thiolester bond. Additionally, the terminal carboxylic acid can engage with primary amines in the presence of activators like EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) and HATU (1-(6-Hexahydro-1H-azepin-1-yl)-1H-1,2,3-triazolo[4,5-b]pyridin-4-yl)methyl)-N-(3-(trifluoromethyl)phenyl)methanamine) to create stable amide bonds. This molecule is designed to enhance the water solubility of compounds in aqueous media, thanks to its hydrophilic PEG linker.
Uses
Used in Pharmaceutical Industry:
Bis-Mal-Lysine-PEG4-acid is used as a conjugation agent for improving the solubility and stability of therapeutic molecules. Its ability to form stable amide bonds with primary amines allows for the creation of drug conjugates with enhanced pharmacokinetic properties, potentially leading to better drug delivery and efficacy.
Used in Bioconjugation:
In the field of bioconjugation, Bis-Mal-Lysine-PEG4-acid serves as a versatile linker for attaching various biological molecules, such as proteins, peptides, and nucleic acids, to other molecules or surfaces. The thiolester bond formation with thiols and amide bond formation with primary amines enable the precise and stable attachment of target molecules, which is crucial for applications like drug development, diagnostics, and research.
Used in Drug Delivery Systems:
Bis-Mal-Lysine-PEG4-acid is utilized as a component in the design of drug delivery systems, particularly for targeted therapies. Its hydrophilic nature and ability to form stable bonds with drugs or drug carriers can improve the solubility, circulation time, and targeting capabilities of therapeutic agents, ultimately enhancing their therapeutic effects and reducing side effects.
Used in Material Science:
In material science, Bis-Mal-Lysine-PEG4-acid can be employed as a building block for the development of novel biocompatible materials. Its reactive groups and hydrophilic nature can be leveraged to create materials with tailored properties, such as hydrogels for tissue engineering or surface coatings with specific biological interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1426164-52-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,1,6 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1426164-52:
(9*1)+(8*4)+(7*2)+(6*6)+(5*1)+(4*6)+(3*4)+(2*5)+(1*2)=144
144 % 10 = 4
So 1426164-52-4 is a valid CAS Registry Number.
1426164-52-4Relevant articles and documents
Branched Discreet PEG Constructs
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Paragraph 0326, (2013/03/26)
Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.
