4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester
CAS No.:1024615-33-5
Molecular Formula:C₂₇H₃₈N₄O₂
Molecular Weight:450.624
Hs Code.:

Synonyms:4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

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Chemical Property of 4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

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Technology Process of 4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

There total 11 articles about 4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1024615-32-4
C₂₇H₃₅N₅O₂

: 75-16-1
methylmagnesium bromide

: 1024615-33-5
4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.bmcl.2008.01.108

Reference yield:

: 1024615-31-3
4-(phenylpyridin-3-ylamino)piperidine-1-carboxylic acid tert-butyl ester

: 1024615-33-5
4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / toluene; water / 3.5 h / 0 - 45 °C

2: toluene / 3.5 h / 106 - 114 °C

3: toluene; tetrahydrofuran / 1.17 h / 20 - 28 °C

With sulfuric acid; In tetrahydrofuran; water; toluene; 2: |Bruylants Amination;
DOI:10.1021/op400250s

Reference yield:

: 62-53-3
aniline

: 1024615-33-5
4'-methyl-4-(phenylpyridin-3-ylamino)[1,4′]-bipiperidinyl-1'-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 1 h

2.1: sodium tris(acetoxy)borohydride / toluene / 3.5 h / 25 - 36 °C

3.1: sodium t-butanolate / toluene / 0.17 h / 20 - 25 °C

3.2: 6.67 h / 97 - 112 °C

4.1: sulfuric acid / toluene; water / 3.5 h / 0 - 45 °C

5.1: toluene / 3.5 h / 106 - 114 °C

6.1: toluene; tetrahydrofuran / 1.17 h / 20 - 28 °C

With sulfuric acid; sodium tris(acetoxy)borohydride; sodium t-butanolate; In tetrahydrofuran; water; toluene; 3.2: |Buchwald-Hartwig Coupling / 5.1: |Bruylants Amination;
DOI:10.1021/op400250s