8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

Base Information

Chemical Name:8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine
CAS No.:160641-93-0
Molecular Formula:C₁₅H₁₁BrCl₃N₃O
Molecular Weight:435.535
Hs Code.:

Synonyms:8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

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Chemical Property of 8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

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Technology Process of 8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

There total 7 articles about 8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: 160641-61-2
3-Bromo-8-(2,4,6-trichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridin

: 160641-93-0
8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

Guidance literature:: With iron; acetic acid; In ethanol; for 0.666667h; Heating;
DOI:10.1021/jm970591c

Reference yield:

: 50-43-1
2,4,6-trichlorobenzoic acid

: 160641-93-0
8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 70percent aq. HNO₃, H₂SO₄ / 1.5 h / 10 °C

2: NaBH₄ / methanol / 1 h / 10 °C

3: Et₃N / CH₂Cl₂

4: K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

5: N-bromosuccinimide / ethanol

6: 94.8 percent / Fe, AcOH / ethanol / 0.67 h / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; sulfuric acid; nitric acid; iron; potassium carbonate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970591c

Reference yield:

: 71372-03-7
2,4,6-trichloro-3-nitrobenzoic acid

: 160641-93-0
8-(3-Amino-2,4,6-trichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol / 1 h / 10 °C

2: Et₃N / CH₂Cl₂

3: K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

4: N-bromosuccinimide / ethanol

5: 94.8 percent / Fe, AcOH / ethanol / 0.67 h / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; iron; potassium carbonate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970591c