(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Base Information

Chemical Name:(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester
CAS No.:947145-74-6
Molecular Formula:C₁₆H₁₄BrN₅O₄
Molecular Weight:420.222
Hs Code.:

Synonyms:(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Suppliers and Price of (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

There total 9 articles about (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947145-72-4
(3-cyano-benzyl)-(2,6-dibromo-3-nitro-pyridin-4-yl)-carbamic acid ethyl ester

: 947145-74-6
(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Guidance literature:: With ammonia; In 2-methyltetrahydrofuran; water; at 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2011.08.119

Reference yield:

: 39771-34-1
4-amino-2,6-dibromopyridine

: 947145-74-6
(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C

2: sulfuric acid / 1.58 h / 47 - 56 °C

3: triethylamine / 2-methyltetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4: potassium carbonate; sodium iodide / acetone / 24 h / Inert atmosphere

5: ammonia / 2-methyltetrahydrofuran; water / 18 h / 20 °C

With sulfuric acid; ammonia; nitric acid; potassium carbonate; triethylamine; sodium iodide; In 2-methyltetrahydrofuran; water; acetone;
DOI:10.1016/j.tetlet.2011.08.119

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 947145-74-6
(2-amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20.75 h / 5 - 20 °C / Inert atmosphere

2: sulfuric acid; nitric acid / 3.92 h / 79 - 85 °C

3: iron; acetic acid / 0.75 h

4: sulfuric acid; nitric acid / 0.5 h / -10 - -5 °C

5: sulfuric acid / 1.58 h / 47 - 56 °C

6: triethylamine / 2-methyltetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

7: potassium carbonate; sodium iodide / acetone / 24 h / Inert atmosphere

8: ammonia / 2-methyltetrahydrofuran; water / 18 h / 20 °C

With sulfuric acid; ammonia; nitric acid; urea hydrogen peroxide adduct; iron; potassium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; sodium iodide; In 2-methyltetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/j.tetlet.2011.08.119