methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate

Base Information

• Chemical Name: methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate
• CAS No.: 959991-22-1
• Molecular Formula: C₂₉H₃₁Cl₂N₃O₆
• Molecular Weight: 588.488
• Mol file: 959991-22-1.mol

Synonyms:methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate

Chemical Property of methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate

There total 4 articles about methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl N-(2,6-dichlorobenzoyl)-L-tyrosinate (938195-80-3) + tert-butyl 6-(bromomethyl)pyridin-2-yl(methyl)carbamate (959991-23-2) → methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate (959991-22-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

(tert-butoxy)-N-methyl-N-[6-methyl-(2-pyridyl)]carboxamide (205676-84-2) → methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate (959991-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 20 - 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

2,6-Dichlorobenzoyl chloride (4659-45-4) → methyl O-({6-[(tert-butoxycarbonyl)(methyl)amino]pyridin-2-yl}methyl)-N-(2,6-dichlorobenzoyl)-L-tyrosinate (959991-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl N-(2,6-dichlorobenzoyl)-L-tyrosinate

tert-butyl 6-(bromomethyl)pyridin-2-yl(methyl)carbamate

L-tyrosine methyl ester HCl

2,6-Dichlorobenzoyl chloride