(+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline

Base Information

• Chemical Name: (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline
• CAS No.: 165394-00-3
• Molecular Formula: C₁₈H₂₁NO
• Molecular Weight: 267.371
• Mol file: 165394-00-3.mol

Synonyms:(+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline

Chemical Property of (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline

There total 2 articles about (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

benzyl bromide (100-39-0) + (-)-(3S)-3,4-dihydro-2,3-dimethyl-1(2H)-isoquinolinone (165393-97-5) → (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline (165394-00-3)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; tert-butyl alcohol; at -78 ℃; for 1h;

DOI:10.1021/jo005693g

Reference yield:

benzyl bromide (100-39-0) + (-)-(3S)-3,4-dihydro-2,3-dimethyl-1(2H)-isoquinolinone (165393-97-5) → (+)-(3S,8aR)-3,4,6,8a-tetrahydro-2,3-dimethyl-8a-(phenylmethyl)-1(2H)-isoquinoline (165394-00-3) + (3S,8aS)-8a-Benzyl-2,3-dimethyl-3,4,6,8a-tetrahydro-2H-isoquinolin-1-one

Guidance literature:

With penta-1,3-diene; ammonia; lithium; tert-butyl alcohol; Yield given; Multistep reaction; 1.) -78 deg C;

DOI:10.1021/jo980921g

upstream raw materials:

benzyl bromide

(-)-(3S)-3,4-dihydro-2,3-dimethyl-1(2H)-isoquinolinone