5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

Base Information

Chemical Name:5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide
CAS No.:1423124-01-9
Molecular Formula:C₂₅H₂₀Cl₂F₃N₃O₂S
Molecular Weight:554.42
Hs Code.:

Synonyms:5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

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Chemical Property of 5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

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Technology Process of 5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

There total 5 articles about 5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1423022-49-4
6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

: 2,4,6-trimethylbenzenesulfonate 1-amino-tetrahydro-λ⁴-thiophenium

: 1423124-01-9
5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

Guidance literature:: With potassium tert-butylate; at 20 ℃;

Reference yield:

: 444993-17-3
4-trifluoromethyl-benzoic acid isopropyl ester

: 1423124-01-9
5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C

1.2: 2 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 20 h / Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.1: triethylamine / acetonitrile / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: potassium tert-butylate / 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; water; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1423124-01-9
5-chloro-2-[[2-(3-chloro-2-pyridyl)-4-(trifluoromethyl)benzoyl]amino]-3-methyl-N-(thiolan-1-ylidene)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 3 h / 20 - 30 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C

2.2: 2 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 20 h / Reflux

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

5.1: triethylamine / acetonitrile / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: potassium tert-butylate / 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; water; triethylamine; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;