6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

Base Information

Chemical Name:6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one
CAS No.:1423022-49-4
Molecular Formula:C₂₁H₁₁Cl₂F₃N₂O₂
Molecular Weight:451.232
Hs Code.:

Synonyms:6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

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Chemical Property of 6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

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Technology Process of 6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

There total 5 articles about 6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1423022-47-2
2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-benzoic acid

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 1423022-49-4
6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

Guidance literature:: 2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-benzoic acid; With triethylamine; In acetonitrile; at 0 ℃; for 0.5h;

2-amino-5-chloro-3-methylbenzoic acid; With methanesulfonyl chloride; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 444993-17-3
4-trifluoromethyl-benzoic acid isopropyl ester

: 1423022-49-4
6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / 0 °C

1.2: 1.5 h / 22 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 30 - 110 °C / Inert atmosphere

2.2: 70 °C

3.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 - 5 °C

3.2: 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; acetonitrile;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1423022-49-4
6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 4 h / 22 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / 0 °C

2.2: 1.5 h / 22 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 30 - 110 °C / Inert atmosphere

3.2: 70 °C

4.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 - 5 °C

4.2: 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; acetonitrile;