N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine
• CAS No.: 143944-89-2
• Molecular Formula: C₁₆H₂₄ClNO₄S
• Molecular Weight: 361.89
• Mol file: 143944-89-2.mol

Synonyms:N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine

Chemical Property of N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine

There total 2 articles about N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-Chloro-1-butanol (928-51-8) + N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine (143944-89-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85630-1

Reference yield:

→ N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine (143944-89-2)

Guidance literature:

Reference yield: 51.0%

N1,N7-di(p-toluenesulfonyl)-1,7-diaminoheptane (81505-98-8) + N-(tert-butyloxycarbonyl)-N-[(4-methylphenyl)sulfonyl]-4-chlorobutylamine (143944-89-2) → 1,6,14,19-tetraaza-1,19-bis-t-butoxycarbonyl-1,6,14,19-tetra-p-toluenesulfonyl-nonadecane (143944-95-0)

Guidance literature:

With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 55 ℃; for 18h;

DOI:10.1016/S0040-4020(01)85630-1

upstream raw materials:

4-Chloro-1-butanol

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

Downstream raw materials:

1,6,14,19-tetraaza-1,19-bis-t-butoxycarbonyl-1,6,14,19-tetra-p-toluenesulfonyl-nonadecane

N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-diamino-5,13-diazaheptadecane

1,19-Bis(tert-butyloxycarbonyl)-1,19-bis[(4-methylphenyl)sulfonyl]-6,14-bis(benzoyl)-1,6,14,19-tetraazanonadecane