4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

Base Information

Chemical Name:4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide
CAS No.:905457-33-2
Molecular Formula:C₂₇H₃₅IN₄O₂
Molecular Weight:574.505
Hs Code.:

Synonyms:4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

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Chemical Property of 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

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Technology Process of 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

There total 11 articles about 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 834-50-4
4-(ethoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid

: 905457-33-2
4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; mercury(II) oxide / dichloromethane / 1 h / 80 - 90 °C / Inert atmosphere

2: potassium hydroxide / ethanol / 20 °C

3: Dichloromethyl methyl ether / chloroform-d1 / 72 h / 50 °C / Inert atmosphere

4: triethylamine / chloroform-d1 / 20 °C / Inert atmosphere

With Dichloromethyl methyl ether; iodine; triethylamine; potassium hydroxide; mercury(II) oxide; In chloroform-d1; ethanol; dichloromethane;
DOI:10.1021/jm1009956

Reference yield:

: 4-iodobicyclo[2.2.2]octyl-1-carboxylic acid chloride

: 155204-28-7
1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine

: 905457-33-2
4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

Guidance literature:: With triethylamine; In chloroform-d1; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm1009956

Reference yield:

: 787-07-5
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

: 905457-33-2
4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)bicyclo[ 2.2.2]octane-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere; Heating

2.1: hydrogenchloride / chloroform / 7 h / 0 °C / Inert atmosphere

3.1: Raney nickel (Ra-Ni) / ethanol / 4 h / Inert atmosphere; Reflux

4.1: potassium hydroxide / ethanol / Reflux

5.1: iodine; mercury(II) oxide / dichloromethane / 1 h / 80 - 90 °C / Inert atmosphere

6.1: potassium hydroxide / ethanol / 20 °C

7.1: Dichloromethyl methyl ether / chloroform-d1 / 72 h / 50 °C / Inert atmosphere

8.1: triethylamine / chloroform-d1 / 20 °C / Inert atmosphere

With hydrogenchloride; Dichloromethyl methyl ether; iodine; sodium hydride; triethylamine; potassium hydroxide; mercury(II) oxide; In 1,2-dimethoxyethane; chloroform-d1; ethanol; dichloromethane; chloroform; mineral oil;
DOI:10.1021/jm1009956