6-Carboxyfluorescein diacetate

Base Information

Chemical Name:6-Carboxyfluorescein diacetate
CAS No.:3348-03-6
Molecular Formula:C25H16O9
Molecular Weight:460.397
Hs Code.:29322090
European Community (EC) Number:878-448-9
DSSTox Substance ID:DTXSID80187121
Nikkaji Number:J227.665H
Wikidata:Q72515526
Mol file:3348-03-6.mol

Synonyms:6-carboxy-3',6'-diacetylfluorescein;6-carboxyfluorescein diacetate;6-CFDA

Suppliers and Price of 6-Carboxyfluorescein diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
6-Carboxyfluoresceine diacetate
50mg
$ 319.00

TRC
6-CarboxyfluoresceinDiacetate
10mg
$ 50.00

TRC
6-CarboxyfluoresceinDiacetate
50mg
$ 115.00

Matrix Scientific
3',6'-Diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid 95+%
1g
$ 1647.00

Matrix Scientific
3',6'-Diacetoxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid 95+%
250mg
$ 742.00

Crysdot
6-CFDA 95+%
50mg
$ 56.00

Crysdot
6-CFDA 95+%
10mg
$ 42.00

Crysdot
6-CFDA 95+%
100mg
$ 98.00

ChemScene
6-CFDA 98.09%
100mg
$ 168.00

ChemScene
6-CFDA 98.09%
50mg
$ 96.00

Total 35 raw suppliers

Chemical Property of 6-Carboxyfluorescein diacetate

Chemical Property:

Vapor Pressure:1.17E-20mmHg at 25°C
Melting Point:152–153°C
Refractive Index:1.701
Boiling Point:701.6 °C at 760 mmHg
PKA:6.4(at 25℃)
Flash Point:245.1 °C
PSA：125.43000
Density:1.57g/cm³
LogP:3.80340
Storage Temp.:2-8°C
Solubility.:DMSO: soluble
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:460.07943208
Heavy Atom Count:34
Complexity:828

Purity/Quality:

99% ^*data from raw suppliers

6-Carboxyfluoresceine diacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)OC(=O)C)C5=C(C=CC(=C5)C(=O)O)C(=O)O3
Uses 6-CARBOXYFLUORESCEIN DIACETATE is used to differentiate viable cells from apoptotic cells. Live cells that are not apoptotic accumulate 6-carboxyfluorescein but do not accumulate annexin 6-Carboxyfluorescein Diacetate is a fluorescent polyanionic probe used to detect changes intracellular pH. In addition, 6-Carboxyfluorescein Diacetate derivatives can be used as staining agents for flow cytometry to visualize cells undergoing apoptosis or necrosis.

Technology Process of 6-Carboxyfluorescein diacetate

There total 3 articles about 6-Carboxyfluorescein diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 76608-15-6
6-carboxyfluorescein

: 3348-03-6
6-carboxyfluorescein diacetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 108-24-7
acetic anhydride

: 3301-79-9
6-carboxyfluorescein

: 3348-03-6
6-carboxyfluorescein diacetate

Guidance literature:: With pyridine; at 110 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2014.04.090

Reference yield:

: 108-24-7
acetic anhydride

: 108-46-3
recorcinol

: 552-30-7,145253-53-8
trimellitic Anhydride

: 3348-03-6
6-carboxyfluorescein diacetate

: 79955-27-4
5-Carboxyfluorescein diacetate

Guidance literature:: recorcinol; trimellitic Anhydride; With zinc dibromide; at 180 ℃; for 1.33333h;

acetic anhydride; for 2h; Overall yield = 4.3 g; Reflux;
DOI:10.1039/c4cc04120h