6-Carboxyfluorescein

Base Information

Chemical Name:6-Carboxyfluorescein
CAS No.:3301-79-9
Molecular Formula:C21H12O7
Molecular Weight:376.322
Hs Code.:3204 90 00
European Community (EC) Number:636-503-2
UNII:JHJ853P6SM
DSSTox Substance ID:DTXSID6062965
Nikkaji Number:J277.784C
Wikipedia:6-Carboxyfluorescein
Wikidata:Q245486
ChEMBL ID:CHEMBL1614944
Mol file:3301-79-9.mol

Synonyms:5(6)-carboxyfluorescein;6-carboxyfluorescein;carboxyfluorescein

Suppliers and Price of 6-Carboxyfluorescein

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
6-Carboxyfluorescein
100mg
$ 403.00

Usbiological
6-Carboxyfluorescein
50mg
$ 333.00

TRC
6-Carboxyfluorescein
50mg
$ 85.00

TCI Chemical
6-Carboxyfluorescein Hydrate >97.0%(HPLC)
100mg
$ 121.00

Sigma-Aldrich
6-Carboxyfluorescein ~97% (HPLC)
50mg
$ 114.00

Sigma-Aldrich
6-Carboxyfluorescein Novabiochem?
25 mg
$ 42.30

Sigma-Aldrich
6-Carboxyfluorescein Novabiochem . CAS 3301-79-9, molar mass 376.32 g/mol., Novabiochem
8510728025
$ 40.90

Sigma-Aldrich
6-Carboxyfluorescein Novabiochem . CAS 3301-79-9, molar mass 376.32 g/mol., Novabiochem
8510728100
$ 120.00

Sigma-Aldrich
6-Carboxyfluorescein Novabiochem?
100 mg
$ 124.00

Medical Isotopes, Inc.
6-Carboxyfluorescein
0.5 g
$ 1720.00

Total 86 raw suppliers

Chemical Property of 6-Carboxyfluorescein

Chemical Property:

Appearance/Colour:Orange solid
Vapor Pressure:9.09E-23mmHg at 25°C
Melting Point:>300 °C(lit.)
Refractive Index:1.816
Boiling Point:736.4 °C at 760 mmHg
PKA:3.3, 4.6, 6.4, 7.0(at 25℃)
Flash Point:271 °C
PSA：113.29000
Density:1.73 g/cm³
LogP:3.36400
Storage Temp.:2-8°C
Solubility.:DMSO: soluble
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:376.05830272
Heavy Atom Count:28
Complexity:637

Purity/Quality:

99% ^*data from raw suppliers

6-Carboxyfluorescein ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC2=C(C=C1C(=O)O)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O
Uses 6-Carboxyfluorescein is derivative of fluorescein giving stable derivative upon conjugation with biopolymers.It has been used to check the plasma membrane integrity in sperm cells.

Technology Process of 6-Carboxyfluorescein

There total 4 articles about 6-Carboxyfluorescein which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-46-3
recorcinol

: 552-30-7,145253-53-8
trimellitic Anhydride

: 3301-79-9
6-carboxyfluorescein

: 76823-03-5
5-carboxyfluoroscein

Guidance literature:: With sulfuric acid; at 130 ℃; for 0.04h; Title compound not separated from byproducts; Irradiation;

Reference yield:

: 100-44-7
benzyl chloride

: 108-46-3
recorcinol

: 552-30-7,145253-53-8
trimellitic Anhydride

: 3301-79-9
6-carboxyfluorescein

: 76823-03-5
5-carboxyfluoroscein

Guidance literature:: recorcinol; trimellitic Anhydride; With zinc(II) chloride; at 200 ℃; for 2h;

benzyl chloride; With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 19h;

With 5%-palladium/activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃;
DOI:10.1016/j.saa.2016.06.021

Reference yield:

: disodium (fluorescein-6-carbonyloxy)acetoaminomethylene bisphosphonate

: 3301-79-9
6-carboxyfluorescein

Guidance literature:: With buffer (KCl, diethylbarbituric acid); In water; at 37 ℃; Rate constant; also in buffers with pH 2, 3, 4, 5, 6, 7, 8, 9 and rat plasma;
DOI:10.1111/j.2042-7158.1996.tb03976.x