(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester
CAS No.:172691-27-9
Molecular Formula:C₂₃H₃₇BrO₅Si
Molecular Weight:501.533
Hs Code.:

Synonyms:(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

Suppliers and Price of (S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

There total 1 articles about (S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 141277-18-1
(3S,4S,5R)-tert-butyl <6-(p-bromobenzyloxy)-4,5-epoxy-3-hydroxy>hexanoate

: 172691-27-9
(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(95)01645-X

Reference yield:

: 172691-27-9
(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

: 172691-23-5
(4S,5S)-5-[(S)-2-(4-Bromo-benzyloxy)-1-hydroxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-dihydro-furan-2-one

Guidance literature:: With chloro-trimethyl-silane; zinc; In dichloromethane; Yield given;
DOI:10.1016/0040-4039(95)01645-X

Reference yield:

: 172691-27-9
(S)-3-[(2R,3R)-3-(4-Bromo-benzyloxymethyl)-oxiranyl]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester

: Benzoic acid (R)-2-(4-bromo-benzyloxy)-1-[(2S,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Me₃SiCl, Zn / CH₂Cl₂

2: 90 percent / pyridine

3: 60 percent / LiAl(OtBu)3H / diethyl ether

4: 90 percent / pyridine / CH₂Cl₂

5: TMSOSO₂CF₃ / acetonitrile; 1,2-dichloro-ethane

With pyridine; chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; lithium tri-t-butoxyaluminum hydride; zinc; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/0040-4039(95)01645-X