(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363478-90-3
Molecular Formula:C₃₁H₂₇N₃O₈S
Molecular Weight:601.637
Hs Code.:

Synonyms:(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Chemical Property of (E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Technology Process of (E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 21 articles about (E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1363479-85-9
(E)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-carboxamide

: 1939-99-7
benzenesulfonyl chloride

: 1363478-90-3
(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 38 ℃; for 0.166667h;
DOI:10.1021/jm201717y

Reference yield:

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1363481-42-8
(7-carbamoyl-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

: 1363478-90-3
(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1021/jm201717y

Reference yield:

: 885227-29-2
tert-butyl 1-(chloromethyl)-7-cyano-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

: 1363478-90-3
(E)-(7-carbamoyl-3-(3(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: pyridine / 2 h / 0 °C

3: sodium iodide / butanone / Reflux

4: acetic acid / 48 h / Reflux

5: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

6: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

7: 1,4-dioxane / 24 h / Inert atmosphere; Reflux

8: triethylamine / dichloromethane / 0.33 h / 0 °C

9: trifluoroacetic acid / dichloromethane / 20 °C

10: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; sulfuric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; acetic acid; dimethyl sulfoxide; butanone;
DOI:10.1021/jm201717y