methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

Base Information

Chemical Name:methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate
CAS No.:406684-81-9
Molecular Formula:C₃₁H₄₁ClN₂O₇
Molecular Weight:589.129
Hs Code.:

Synonyms:methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

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Chemical Property of methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

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Technology Process of methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

There total 9 articles about methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: [(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid

: 406684-80-8
methyl N-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

: 406684-81-9
methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1016/S0968-0896(01)00290-5

Reference yield:

: 7033-50-3
6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one

: 406684-81-9
methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h

1.2: 37 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.1: 87 percent / NaBH₄ / ethanol / 4 h

3.1: 100 percent / NaBH₃CN; AcOH / methanol / 1 h / 20 °C

4.1: 92 percent / NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

5.1: 90 percent / K₂CO₃ / ethanol / 24 h

6.1: 76 percent / K₂CO₃ / methanol; H₂O / 20 °C

7.1: 43 percent / DEPC; Et₃N / dimethylformamide / 0.5 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00290-5

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 406684-81-9
methyl N-[(3S,5R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-neopentyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]-L-leucinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h

1.2: 37 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.1: 87 percent / NaBH₄ / ethanol / 4 h

3.1: 100 percent / NaBH₃CN; AcOH / methanol / 1 h / 20 °C

4.1: 92 percent / NaHCO₃ / CH₂Cl₂ / 2 h / 20 °C

5.1: 90 percent / K₂CO₃ / ethanol / 24 h

6.1: 76 percent / K₂CO₃ / methanol; H₂O / 20 °C

7.1: 43 percent / DEPC; Et₃N / dimethylformamide / 0.5 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00290-5