N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide
CAS No.:1544263-66-2
Molecular Formula:C₂₀H₁₆BrF₃N₂O₆
Molecular Weight:517.256
Hs Code.:

Synonyms:N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

There total 3 articles about N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1544264-34-7
C₁₈H₁₇BrN₂O₅

: 407-25-0
trifluoroacetic anhydride

: 1544263-66-2
N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1039/c3ob42314j

Reference yield:

: 54370-00-2
2-bromo-4,5-dimethoxybenzyl alcohol

: 1544263-66-2
N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c3ob42314j

Reference yield:

: 1354640-55-3
1-bromo-4,5-dimethoxy-2-[(prop-2-ynyloxy)methyl]benzene

: 1544263-66-2
N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 2 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c3ob42314j