1354640-55-3

Upstream product

• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 106-96-7 propargyl bromide 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 

Downstream Products

• 1354640-60-0 2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)thiophene 
• 1354640-70-2 C₁₈H₁₈O₃ 
• 1354640-71-3 6,7-dimethoxy-4-(4-methylbenzylidene)isochroman 
• 1354640-72-4 C₁₉H₂₀O₃ 
• 1354640-73-5 C₁₉H₂₀O₄ 
• 1354640-75-7 C₂₇H₂₅NO₅S 
• 1354640-58-6 1-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-3-methylbenzene 
• 1354640-57-5 1-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-methylbenzene 
• 1354640-61-1 3-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-1-tosyl-1H-indole 
• 1544264-31-4 C₁₉H₂₀BrNO₃ 
• 1544264-34-7 C₁₈H₁₇BrN₂O₅ 
• 1544264-29-0 C₁₈H₁₈BrNO₃ 
• 1544263-66-2 N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-nitrophenyl)-2,2,2-trifluoroacetamide 
• 1544263-64-0 N-(2-(3-(2-bromo-4,5-dimethoxybenzyloxy)prop-1-ynyl)-4-methylphenyl)-2,2,2-trifluoroacetamide 

Relevant academic research and scientific papers

Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: Selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4- tetrahydroisoquinolines and aze/oxepinoindoles

Palladium-catalyzed highly regio- and stereoselective 6-exo-dig and 7-endo-dig cyclization of functionalized propargylic compounds has been developed for the synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4- tetrahydroisoquinolines and aze/oxepinoindoles.

Palladium-catalyzed intramolecular hydroarylation of 2-bromobenzyl propargyl ethers: A new access to exocyclic isochromans

An efficient, stereo- and regioselective palladium-catalyzed 6-exo-dig intramolecular hydroarylation of propargyl ethers which provides a concise access to functionalized isochromans in high yields has been developed. A wide range of substrates possessing aromatic, aliphatic and heteroaromatic alkynes can be efficiently transformed into the targeted isochromans. Irrespective of the nature of the substrates, the cyclization follows highly selective -stereo- and regiochemistry.