2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione

Base Information

• Chemical Name: 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione
• CAS No.: 851976-81-3
• Molecular Formula: C₁₉H₁₈FNO₂S
• Molecular Weight: 343.422

Synonyms:2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione

Chemical Property of 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione

Chemical Property:

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Technology Process of 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione

There total 2 articles about 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

bis(4-fluorophenyl)disulfide (405-31-2) + (S)-2-[1-(hydroxymethyl)-2-methylpropyl]-1H-isoindole-1,3(2H)-dione (152903-42-9) → 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione (851976-81-3)

Guidance literature:

With tributylphosphine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.02.011

Reference yield: 10.0%

4-Fluorothiophenol (371-42-6) + (+)-N,N-Phthaloyl-O1-tosyl-L-valinol (152903-45-2) → 2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione (851976-81-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1016/j.bmc.2005.02.011

Reference yield: 45.0%

2-[1-(4-fluorophenylsulfanylmethyl)-2-methyl-propyl]-isoindole-1,3-dione (851976-81-3) → 2-{1-[fluoro-(4-fluorophenylsulfanyl)-methyl]-2-methyl-propyl}-isoindole-1,3-dione (851976-85-7)

Guidance literature:

With Selectfluor; triethylamine; In acetonitrile; at 20 ℃; for 0.666667h;

DOI:10.1016/j.bmc.2005.02.011

upstream raw materials:

4-Fluorothiophenol

(+)-N,N-Phthaloyl-O¹-tosyl-L-valinol

bis(4-fluorophenyl)disulfide

(S)-2-[1-(hydroxymethyl)-2-methylpropyl]-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

2-{1-[fluoro-(4-fluorophenylsulfanyl)-methyl]-2-methyl-propyl}-isoindole-1,3-dione

1-[fluoro-(4-fluorophenylsulfanyl)-methyl]-2-methyl-propylamine

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