152903-45-2Relevant academic research and scientific papers
Investigation of the importance of nitrogen substituents in a N-P chiral ligand for enantioselective allylic alkylation
Anderson, James C.,Cubbon, Rachel J.,Harling, John D.
, p. 923 - 935 (2007/10/03)
The synthesis of three chiral chelate nitrogen-phosphorus (S)-valine derived ligands with the potential for stereogenic nitrogen donation is described. In palladium catalysed allylic substitution reactions the ligands induced varying enantioselectivities ranging from 92% e.e. of the (R)-enantiomer to 83% e.e. of the (S)-enantiomer. Structural and spectroscopic investigations into the origin of this effect were conducted, but were inconclusive. However, the importance of the consideration of N-substituents in such systems is highlighted.
Syntheses and Investigations of isoindol-9b(2H)-yl>phosphinates and -phosphonates: a New Class of Heterocycles
Neidlein, Richard,Greulich, Peter,Kramer, Walter
, p. 2407 - 2417 (2007/10/02)
We attempted to synthesize diethyl (1-methyl-2-phthalimidoethyl)phosphonate (14a) in a Michaelis-Becker reaction using diethyl sodiophosphonate (13) and the tosylate 12a of (2-hydroxypropyl)phthalimide as starting materials.Instead of TsO substitution in
