Technology Process of 2-(2,6-dichlorobenzyl)-4-chloro-1,6-naphthyridin-5(6)-one
There total 8 articles about 2-(2,6-dichlorobenzyl)-4-chloro-1,6-naphthyridin-5(6)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 6-(2,6-dichlorobenzyl)-4-chloro-2-methylpyridine-3-carboxylate;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
1,3,5-Triazine;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 18h;
- Guidance literature:
-
ethyl 6-(2,6-dichlorobenzyl)-4-chloro-2-methylpyridine-3-carboxylate;
With
sodium hydride;
In
mineral oil;
at 20 ℃;
for 0.25h;
Inert atmosphere;
N,N-dimethyl-formamide;
With
1,3,5-Triazine;
In
mineral oil;
at 100 ℃;
for 18h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
1.2: 18 h / 70 °C
2.1: magnesium sulfate; sodium cyanoborohydride; ammonium acetate / 18 h / 70 °C
3.1: magnesium sulfate; acetic acid / toluene / 3 h / 110 °C
4.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C
5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 18.08 h / 20 °C
6.1: trichlorophosphate / 2.5 h / 102 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
7.2: 18 h / 100 °C
With
potassium tert-butylate; ammonium acetate; sodium hydride; sodium cyanoborohydride; magnesium sulfate; acetic acid; 1,1'-carbonyldiimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
