Technology Process of 6-{4-[trans-4-(2-hydroxyethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxamide
There total 13 articles about 6-{4-[trans-4-(2-hydroxyethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-((1R,4R)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid;
With
4-methyl-morpholine; chloroformic acid ethyl ester;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
With
sodium tetrahydroborate;
In
tetrahydrofuran; water;
at 0 - 5 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / propyl cyanide / 0.17 h / 150 °C / Microwave irradiation
2.1: ammonia / methanol / 20 °C
3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 16 h / 80 °C
4.1: potassium hydroxide / tert-butyl alcohol / 0.33 h / 40 °C
4.2: 0.33 h
5.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 3 h / 0 °C
5.2: 0.5 h / 0 - 5 °C
With
4-methyl-morpholine; potassium phosphate; ammonia; chloroformic acid ethyl ester; potassium hydroxide; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; propyl cyanide; ethanol; water; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: manganese(IV) oxide / dichloromethane / 2.17 h / 20 - 35 °C
2.1: trichlorophosphate / propyl cyanide / 0.17 h / 150 °C / Microwave irradiation
3.1: ammonia / methanol / 20 °C
4.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 16 h / 80 °C
5.1: potassium hydroxide / tert-butyl alcohol / 0.33 h / 40 °C
5.2: 0.33 h
6.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 3 h / 0 °C
6.2: 0.5 h / 0 - 5 °C
With
4-methyl-morpholine; manganese(IV) oxide; potassium phosphate; ammonia; chloroformic acid ethyl ester; potassium hydroxide; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; propyl cyanide; ethanol; dichloromethane; water; tert-butyl alcohol;
