AZD-7687

Base Information

• Chemical Name: AZD-7687
• CAS No.: 1166827-44-6
• Molecular Formula: C21H25N3O3
• Molecular Weight: 367.448
• Mol file: 1166827-44-6.mol

Synonyms:AZD 7687;AZD7687;AZD-7687;[trans-4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid

Chemical Property of AZD-7687

Chemical Property:

• Boiling Point: 527.5±50.0 °C(Predicted)
• PKA: 4.72±0.10(Predicted)
• PSA: 107.16000
• Density: 1.201±0.06 g/cm3(Predicted)
• LogP: 4.49200
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

AZD7687 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AZD7687 is a novel, potent, selective and reversible inhibitor of diglyceride acyltransferase-1 (DGAT-1).

Technology Process of AZD-7687

There total 12 articles about AZD-7687 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetate (1166827-45-7) → 2-((1R,4R)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid (1166827-44-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 79.0%

methyl 2-((1s,4s)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetate (1166831-68-0) → 2-((1R,4R)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid (1166827-44-6)

Guidance literature:

methyl 2-((1s,4s)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetate; With potassium hydroxide; In tert-butyl alcohol; at 40 ℃; for 0.333333h;

With acetic acid; In ethanol; tert-butyl alcohol; for 0.333333h;

Reference yield:

ethyl 3,5-dimethyl-6-oxo-1,6-dihydropyrazine-2-carboxylate (1166827-49-1) → 2-((1R,4R)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid (1166827-44-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trichlorophosphate / propyl cyanide / 0.17 h / 150 °C / Microwave irradiation

2.1: ammonia / methanol / 20 °C

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 16 h / 80 °C

4.1: potassium hydroxide / tert-butyl alcohol / 0.33 h / 40 °C

4.2: 0.33 h

With potassium phosphate; ammonia; potassium hydroxide; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; propyl cyanide; ethanol; water; tert-butyl alcohol;

upstream raw materials:

methyl 2-((1s,4s)-4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetate

tert-butyl {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetate

6-chloro-3,5-dimethylpyrazine-2-carboxamide

ethyl 6-chloro-3,5-dimethylpyrazine-2-carboxylate

Downstream raw materials:

6-{4-[trans-4-(2-hydroxyethyl)cyclohexyl]phenyl}-3,5-dimethylpyrazine-2-carboxamide