Masoprocol

Base Information Edit

Chemical Name:Masoprocol
CAS No.:27686-84-6
Deprecated CAS:334707-72-1,741285-10-9,1050512-02-1,741285-10-9
Molecular Formula:C₁₈H₂₂O₄
Molecular Weight:302.37
Hs Code.:
European Community (EC) Number:248-606-6
UNII:7BO8G1BYQU
DSSTox Substance ID:DTXSID5045178
Nikkaji Number:J257.424A
Wikipedia:Masoprocol
Wikidata:Q6783851
NCI Thesaurus Code:C701
RXCUI:227239
Pharos Ligand ID:NPKM56RHNKN7
Metabolomics Workbench ID:42587
ChEMBL ID:CHEMBL313972
Mol file:27686-84-6.mol

Synonyms:1,2-Benzenediol,4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)- (9CI);Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-,meso- (8CI);Actinex;CHX 100;Masoprocol;meso-NDGA;meso-Nordihydroguaiareticacid;4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol;1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-;4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol];4,4'-(2,3-Dimethylbutane-1,4-diyl)dibenzene-1,2-diol;

Suppliers and Price of Masoprocol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Masoprocol 95+%
1g
$ 947.00

Biosynth Carbosynth
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (r*,s*)-
25 mg
$ 409.00

Biosynth Carbosynth
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (r*,s*)-
10 mg
$ 205.00

Biosynth Carbosynth
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (r*,s*)-
5 mg
$ 118.00

Biosynth Carbosynth
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (r*,s*)-
2 mg
$ 59.00

Biosynth Carbosynth
1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (r*,s*)-
50 mg
$ 712.00

American Custom Chemicals Corporation
MASOPROCOL 95.00%
5G
$ 603.00

American Custom Chemicals Corporation
MASOPROCOL 95.00%
1G
$ 468.00

American Custom Chemicals Corporation
MASOPROCOL 95.00%
500MG
$ 434.00

Total 38 raw suppliers

Chemical Property of Masoprocol Edit

Chemical Property:

Appearance/Colour:crystals
Vapor Pressure:1.06E-11mmHg at 25°C
Melting Point:185.5°C
Refractive Index:1.626
Boiling Point:526.5 °C at 760 mmHg
Flash Point:247.8 °C
PSA：80.92000
Density:1.241 g/cm³
LogP:3.56640
Storage Temp.:2-8°C
XLogP3:4.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:302.15180918
Heavy Atom Count:22
Complexity:303

Purity/Quality:

99%, ^*data from raw suppliers

Masoprocol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O
Isomeric SMILES:C[C@H](CC1=CC(=C(C=C1)O)O)[C@@H](C)CC2=CC(=C(C=C2)O)O
Recent ClinicalTrials:Pharmacokinetic and Efficacy Study of Nordihydroguaiaretic Acid (NDGA) in Non Metastatic Recurrent Prostate Cancer
Description Masoprocol is a lipoxygenase inhibitor launched as a topical agent for the treatment of solar or actinic keratoses. It is the first new topical treatment for pre-malignant skin lesions introduced in twenty years. Masoprocol is obtained from the Larrea tridentata plant and is also under investigation for the treatment of lung, breast, colon and ovarian cancers.
Uses Antineoplastic.

Technology Process of Masoprocol

There total 34 articles about Masoprocol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.26%