N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide

Base Information

• Chemical Name: N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide
• CAS No.: 1470134-28-1
• Molecular Formula: C₂₂H₂₈N₆O₆S
• Molecular Weight: 504.567
• Mol file: 1470134-28-1.mol

Synonyms:N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide

Chemical Property of N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide

There total 2 articles about N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

N,N'-[6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diyl]diacetamide (1470134-38-3) + toluene-4-sulfonamide (70-55-3) → N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide (1470134-28-1) + N-[7-(cyclohexylmethoxy)[1,2,5[oxadiazolo][3,4-d]pyrimidin-5-yl]]acetamide (1470134-40-7)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; acetonitrile; at 40 ℃; for 20h;

DOI:10.1016/j.ejmech.2013.07.031

Reference yield:

NU 6027 (220036-08-8) → N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide (1470134-28-1) + N-[7-(cyclohexylmethoxy)[1,2,5[oxadiazolo][3,4-d]pyrimidin-5-yl]]acetamide (1470134-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 h / 50 °C

2: [bis(acetoxy)iodo]benzene / acetonitrile; dichloromethane / 20 h / 40 °C

With [bis(acetoxy)iodo]benzene; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2013.07.031

Reference yield: 59.0%

N,N′-{6-(cyclohexylmethoxy)-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diyl}diacetamide (1470134-28-1) → 6-cyclohexylmethoxy-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diamine (1470134-29-2)

Guidance literature:

With zinc(II) chloride; In ethanol; at 65 ℃; for 48h;

DOI:10.1016/j.ejmech.2013.07.031

upstream raw materials:

N,N'-[6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diyl]diacetamide

toluene-4-sulfonamide

NU 6027

Downstream raw materials:

6-cyclohexylmethoxy-5-{[(4-methylphenyl)sulfonyl]-NNO-azoxy}pyrimidine-2,4-diamine