2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene

Base Information

• Chemical Name: 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene
• CAS No.: 1416136-86-1
• Molecular Formula: C₄₁H₄₈N₂O₅
• Molecular Weight: 648.843
• Mol file: 1416136-86-1.mol

Synonyms:2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene

Chemical Property of 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene

There total 3 articles about 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-[3-(benzyloxy)phenyl]-1,1-bis(4-hydroxyphenyl)-1-butene (1416136-82-7) + 4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene (1416136-86-1)

Guidance literature:

2-[3-(benzyloxy)phenyl]-1,1-bis(4-hydroxyphenyl)-1-butene; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

4-(2-chloroethyl)morpholine hydrochride; With ammonium chloride; In N,N-dimethyl-formamide; at 50 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.10.037

Reference yield:

4,4'-Dihydroxybenzophenone (611-99-4) → 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene (1416136-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc; titanium tetrachloride; potassium carbonate / tetrahydrofuran / 2 h / 0 - 90 °C / Darkness; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 6 h / 50 °C / Inert atmosphere

With titanium tetrachloride; sodium hydride; potassium carbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.10.037

Reference yield:

3-benzyloxyphenyl ethyl ketone (37951-47-6) → 2-[3-(benzyloxy)phenyl]-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene (1416136-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc; titanium tetrachloride / tetrahydrofuran / 2 h / 0 - 90 °C / Darkness

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C

2.2: 6 h / 50 °C

With titanium tetrachloride; sodium hydride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4,4'-Dihydroxybenzophenone

2-[3-(benzyloxy)phenyl]-1,1-bis(4-hydroxyphenyl)-1-butene

4-(2-chloroethyl)morpholine hydrochride

3-benzyloxyphenyl ethyl ketone

Downstream raw materials:

2-(3-hydroxyphenyl)-1,1-bis{4-[2-(morpholin-4-yl)ethoxy]phenyl}-1-butene

Refernces

• 1、 Tsukuda, Senko,Kusayanagi, Tomoe,Umeda, Eri,Watanabe, Chihiro,Tosaki, Yu-Ta,Kamisuki, Shinji,Takeuchi, Toshifumi,Takakusagi, Yoichi,Shiina, Isamu,Sugawara, Fumio. "Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2". . p. 311 - 320. Retrieved 2013/02/23.