1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate
CAS No.:1131042-28-8
Molecular Formula:C₃₁H₄₂BClN₄O₇
Molecular Weight:628.961
Hs Code.:

1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

Synonyms:1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

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Chemical Property of 1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

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Technology Process of 1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

There total 2 articles about 1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1131041-74-1
1,1-dimethylethyl (5-bromo-6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: 201733-56-4
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: C₂₈H₃₆BClN₄O₆

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

Guidance literature:: With potassium acetate; Pd(ddpf)Cl₂ with/without CH₂Cl₂; In tetrahydrofuran; at 70 - 85 ℃; Inert atmosphere;

Reference yield: 87.0%

: 1131041-74-1
1,1-dimethylethyl (5-bromo-6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: 201733-56-4
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In tetrahydrofuran; for 7h; Reflux;
DOI:10.1016/j.bmcl.2009.11.061

Reference yield: 71.0%

: 1131042-22-2
5-bromo-3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridine

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: 1131042-29-9
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; water; for 2h; Reflux;
DOI:10.1016/j.bmcl.2009.11.061