1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

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Chemical Name:1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate
CAS No.:1131042-29-9
Molecular Formula:C₃₉H₄₂ClN₇O₇S
Molecular Weight:788.324
Hs Code.:

1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

Synonyms:1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

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Chemical Property of 1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

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Technology Process of 1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

There total 3 articles about 1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1131042-22-2
5-bromo-3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridine

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: 1131042-29-9
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; water; for 2h; Reflux;
DOI:10.1016/j.bmcl.2009.11.061

Reference yield: 60.0%

: 1131042-22-2
5-bromo-3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridine

: 1131042-33-5
1,1-dimethylethyl [6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamate

: 1131042-29-9
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 75 ℃; for 2.517h; Inert atmosphere;

Reference yield: 48.0%

: 1131042-22-2
5-bromo-3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridine

: C₂₈H₃₆BClN₄O₆

: 1131042-28-8
1,1-dimethylethyl (6-chloro-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-2-pyridinyl)carbamate

: C₃₆H₃₆ClN₇O₆S

: 1131042-29-9
1,1-dimethylethyl {6-chloro-3-{[(2S)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-(1H-indol-3-yl)propyl]oxy}-5-[3-methyl-1-(phenylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-5-yl]-2-pyridinyl}carbamate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 85 ℃; for 2h;