3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

Base Information

Chemical Name:3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel
CAS No.:170241-01-7
Molecular Formula:C₄₂H₅₁Cl₆NO₁₆
Molecular Weight:1038.58
Hs Code.:

Synonyms:3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

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Chemical Property of 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

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Technology Process of 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

There total 3 articles about 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 13-<<(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidin-5-yl>carbonyl>-10-deacetyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>baccatin III

: 170241-01-7
3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

Guidance literature:: With formic acid; for 24h; Ambient temperature;
DOI:10.1021/jm00019a012

Reference yield:

: 95603-44-4
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

: 170241-01-7
3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

With dmap; formic acid; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1021/jm00019a012

Reference yield:

: 170240-99-0
(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid

: 170241-01-7
3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

With dmap; formic acid; dicyclohexyl-carbodiimide; In toluene;
DOI:10.1021/jm00019a012