(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

Base Information

Chemical Name:(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine
CAS No.:106367-81-1
Molecular Formula:C₃₃H₃₅ClN₂O₆S
Molecular Weight:623.17
Hs Code.:

Synonyms:(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

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Chemical Property of (+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

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Technology Process of (+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

There total 4 articles about (+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.5%

: 3-Chloro-benzoic acid (3aS,5aS,10bR,12bS)-3a-ethyl-5a-hydroxy-6-(4-methoxy-benzenesulfonyl)-12a-oxy-2,3,3a,4,5,5a,6,11,12,12b-decahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-5-yl ester

: 106367-81-1
(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

Guidance literature:: With triphenylphosphine; In water; acetic acid; at 20 ℃; for 72h;
DOI:10.1016/S0040-4020(01)87386-5

Reference yield:

: 85924-17-0
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-phenylthio-aspidospermidin-10-one

: 106367-81-1
(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

Guidance literature:: Multi-step reaction with 4 steps

1: 140 mg / Lawesson's reagent / toluene / 1 h / 80 °C

2: 77.5 mg / Raney nickel / ethanol; tetrahydrofuran / 0.75 h

3: CH₂Cl₂; benzene / 22 h / 20 °C

4: 36.5 percent / PPh₃ / acetic acid; H₂O / 72 h / 20 °C

With Lawessons reagent; triphenylphosphine; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; toluene; benzene;
DOI:10.1016/S0040-4020(01)87386-5

Reference yield:

: 106367-83-3
(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

: 106367-81-1
(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

Guidance literature:: Multi-step reaction with 3 steps

1: 77.5 mg / Raney nickel / ethanol; tetrahydrofuran / 0.75 h

2: CH₂Cl₂; benzene / 22 h / 20 °C

3: 36.5 percent / PPh₃ / acetic acid; H₂O / 72 h / 20 °C

With triphenylphosphine; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; benzene;
DOI:10.1016/S0040-4020(01)87386-5