(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

Base Information

Chemical Name:(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol
CAS No.:1315336-61-8
Molecular Formula:C₃₃H₅₃N₅O₄Si₂
Molecular Weight:639.986
Hs Code.:

Synonyms:(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

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Chemical Property of (4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

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Technology Process of (4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

There total 6 articles about (4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1315336-60-7
methyl 4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl)benzoate

: 1315336-61-8
(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.00555556h; Inert atmosphere;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-57-2
methyl 4-(2-(2-(allyloxy)-4-nitrophenyl)-2H-tetrazol-5-yl)benzoate

: 1315336-61-8
(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; water; iron; acetic acid / Sonication

2: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

3: 1H-imidazole; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.01 h / 0 °C / Inert atmosphere

With 1H-imidazole; methanol; lithium aluminium tetrahydride; ethanol; water; iron; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja204758c

Reference yield:

: 351188-76-6
(E)-methyl 4-((2-(phenylsulfonyl)hydrazono)methyl)benzoate

: 1315336-61-8
(4-(2-(2-(allyloxy)-4-(bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)phenyl)-2H-tetrazol-5-yl) phenyl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / -20 °C

2: ethanol; water; iron; acetic acid / Sonication

3: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

4: 1H-imidazole; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5: lithium aluminium tetrahydride / tetrahydrofuran / 0.01 h / 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; methanol; lithium aluminium tetrahydride; ethanol; water; iron; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja204758c