(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

Base Information

Chemical Name:(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan
CAS No.:144918-24-1
Molecular Formula:C₂₃H₂₈O₆
Molecular Weight:400.472
Hs Code.:

Synonyms:(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

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Chemical Property of (2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

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Technology Process of (2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

There total 5 articles about (2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 144918-23-0
2-(3,4-dimethoxyphenyl)-3-(hydroxymethyl)-4-methylenetetrahydrofuran

: 7306-46-9
4-chloromethyl-1,2-dimethoxy-benzene

: 144918-24-1
(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

Guidance literature:: With sodium hydride; In 1,2-dimethoxyethane; for 20h; Heating;
DOI:10.1016/S0040-4039(00)61118-8 DOI:10.1016/S0040-4020(01)81924-4

Reference yield:

: 144918-21-8
ethyl 2-bromo-3-(3,4-dimethoxyphenyl)-3-(prop-2-ynyloxy)propanoate

: 144918-24-1
(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / n-Bu₃SnH, AIBN / benzene / 4 h / Heating

2: 97 percent / LiAlH₄ / diethyl ether / 3 h / Heating

3: 76 percent / NaH / 1,2-dimethoxy-ethane / 20 h / Heating

With lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In 1,2-dimethoxyethane; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)81924-4

Reference yield:

: 144918-22-9
ethyl rac-(2R,3R)-2-(3,4-dimethoxyphenyl)-4-methylenetetrahydrofuran-3-carboxylate

: 144918-24-1
(2R,3S)-3-(3,4-Dimethoxy-benzyloxymethyl)-2-(3,4-dimethoxy-phenyl)-4-methylene-tetrahydro-furan

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiAlH₄ / diethyl ether / 3 h / Heating

2: 76 percent / NaH / 1,2-dimethoxy-ethane / 20 h / Heating

With lithium aluminium tetrahydride; sodium hydride; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1016/S0040-4020(01)81924-4