Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester

Base Information

• Chemical Name: Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester
• CAS No.: 186410-30-0
• Molecular Formula: C₂₈H₄₃NO₃SeSi
• Molecular Weight: 548.7
• Mol file: 186410-30-0.mol

Synonyms:Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester

Chemical Property of Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester

There total 5 articles about Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester (186410-30-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 2,6-lutidine

2: DIBALH

4: 1.) Et₂O, 0 deg C to room temp., 2.) Et₂O, toluene, -10 deg C, 1 h

With 2,6-dimethylpyridine; diisobutylaluminium hydride;

DOI:10.1016/S0040-4039(96)02160-0

Reference yield:

(S)-2-Triisopropylsilanyloxy-propionic acid methyl ester → Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester (186410-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: DIBALH

3: 1.) Et₂O, 0 deg C to room temp., 2.) Et₂O, toluene, -10 deg C, 1 h

With diisobutylaluminium hydride;

DOI:10.1016/S0040-4039(96)02160-0

Reference yield:

diphenyl diselenide (1666-13-3) + chloroformic acid ethyl ester (541-41-3) + Benzyl-[(S)-2-triisopropylsilanyloxy-prop-(E)-ylidene]-amine → Benzyl-((S)-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester (204715-09-3) + Benzyl-((S)-1-phenylselanyl-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester (186410-30-0)

Guidance literature:

With diisobutylaluminium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) Et₂O, r.t., 2.) Et₂O, toluene, r.t., 3 h;

DOI:10.1002/hlca.19980810216

upstream raw materials:

chloroformic acid ethyl ester

phenylselanyldiisobutylaluminum

diphenyl diselenide

triisopropylsilyl trifluoromethanesulfonate

Downstream raw materials:

Benzyl-((S)-2-hydroxy-propyl)-carbamic acid ethyl ester

Benzyl-((S)-2-triisopropylsilanyloxy-propyl)-carbamic acid ethyl ester

(4S,5S)-4-(Benzyl-ethoxycarbonyl-amino)-2-methylene-5-triisopropylsilanyloxy-hexanoic acid methyl ester

(4R,5S)-4-(Benzyl-ethoxycarbonyl-amino)-2-methylene-5-triisopropylsilanyloxy-hexanoic acid methyl ester