4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole
• CAS No.: 1034292-94-8
• Molecular Formula: C₁₈H₁₈N₄O₆
• Molecular Weight: 386.364
• Mol file: 1034292-94-8.mol

Synonyms:4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Chemical Property of 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

There total 5 articles about 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-ethynyl-1-methoxy-2-nitrobenzene (105752-18-9) + 3,4,5-trimethoxyphenyl azide (115483-29-9) → 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1034292-94-8)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol;

DOI:10.1016/j.bmc.2010.07.032

Reference yield: 34.0%

4-ethynyl-1-methoxy-2-nitrobenzene (105752-18-9) + 3,4,5-trimethoxyphenyl azide (115483-29-9) → 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1034292-94-8) + C18H18N4O6 (1034292-87-9)

Guidance literature:

In ethanol; water; for 48h; Heating;

DOI:10.1016/j.bmc.2008.03.049

Reference yield:

4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane (214360-67-5) → 4-(4-methoxy-3-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (1034292-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; copper(II) bis(trifluoromethanesulfonate) / ethanol / 12 h / 40 °C

2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate / water / 14 h / 20 °C / Inert atmosphere

With sodium azide; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(II) bis(trifluoromethanesulfonate); In ethanol; water;

DOI:10.1002/chem.201403021

upstream raw materials:

4-ethynyl-1-methoxy-2-nitrobenzene

3,4,5-trimethoxyphenyl azide

4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane

1,2,3-trimethoxybenzene

Downstream raw materials:

2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-4-yl)aniline