4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane

Base Information

• Chemical Name: 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane
• CAS No.: 214360-67-5
• Molecular Formula: C15H23BO5
• Molecular Weight: 294.156
• Hs Code.: 2934999090
• Mol file: 214360-67-5.mol

Synonyms:4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane;

Chemical Property of 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane

Chemical Property:

• Melting Point: 100-101.5 °C
• Boiling Point: 385.6±42.0 °C(Predicted)
• PSA: 46.15000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 2.01160
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane

There total 29 articles about 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,2,3-trimethoxybenzene (634-36-6) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane (214360-67-5)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cyclopentyl methyl ether; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole; at 100 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.5b05252

Reference yield: 89.0%

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) + 1-bromo-3,4,5-trimethoxybenzene (2675-79-8) → 4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane (214360-67-5)

Guidance literature:

1-bromo-3,4,5-trimethoxybenzene; With n-butyllithium; In tetrahydrofuran;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran;

DOI:10.1039/c5sm02489g

Reference yield: 85.0%

1-bromo-3,4,5-trimethoxybenzene (2675-79-8) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(3,4,5-trimethoxyphenyl)-1,3,2-dioxaborolane (214360-67-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200900234

upstream raw materials:

1-bromo-3,4,5-trimethoxybenzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

2,3-dimethyl-2,3-butane diol

Downstream raw materials:

4-(3,4,5-trimethoxyphenyl)pyridine-2,6-diamine hydrochloride

2,4,6-tris[5-(3,4,5-trimethoxyphenyl)thiophen-2-yl]-1,3,5-triazine

(1,2,3-trimethoxy)-5-(trifluoromethyl)benzene

1-phenyl-3-(3,4,5-trimethoxyphenyl-)propane