methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

Base Information

Chemical Name:methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate
CAS No.:1147857-81-5
Molecular Formula:C₂₃H₃₄N₂O₄Si
Molecular Weight:430.619
Hs Code.:

Synonyms:methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

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Chemical Property of methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

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Technology Process of methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

There total 4 articles about methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99548-54-6
methyl 3-bromo-2-methylbenzoate

: 1147857-81-5
methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / triphenylphosphine; bis(triphenylphosphine)benzylideneruthenium(II) dichloride / 1,4-dioxane / 20 - 100 °C / Inert atmosphere

2: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / ethyl acetate; toluene; water / 24 h / 80 °C / Inert atmosphere

With potassium phosphate; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(triphenylphosphine)benzylideneruthenium(II) dichloride; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; ethyl acetate; toluene;

Reference yield:

: 955929-54-1
methyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzoate

: 1147857-73-5
5-bromo-2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidine

: 1147857-81-5
methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

Guidance literature:: With potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In water; ethyl acetate; toluene; at 80 ℃; for 24h; Inert atmosphere;

Reference yield:

: 76006-33-2
3-bromo-2-methylbenzoic acid

: 1147857-81-5
methyl 3-[2-(2-{[tert-butyl(dimethyl)silyl]oxy}ethoxy)-4,6-dimethylpyrimidin-5-yl]-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 22 h / Reflux

1.2: pH 7 - 8

2.1: potassium acetate / triphenylphosphine; bis(triphenylphosphine)benzylideneruthenium(II) dichloride / 1,4-dioxane / 20 - 100 °C / Inert atmosphere

3.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / ethyl acetate; toluene; water / 24 h / 80 °C / Inert atmosphere

With potassium phosphate; sulfuric acid; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(triphenylphosphine)benzylideneruthenium(II) dichloride; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; ethyl acetate; toluene;