99548-54-6

Basic information

• Product Name: 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER
• Synonyms: 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER;METHYL 3-BROMO-2-METHYLBENZOATE;3-BroMo-2-Methyl-benzoic acid Methy;Benzoic acid, 3-broMo-2-Methyl-, Methyl ester;3-BroMo-o-toluic Acid Methyl Ester;Methyl 3-bromo-2-methylbenzoate 97%;Methyl 3-bromo-o-toluate, 2-Bromo-6-(methoxycarbonyl)toluene
• CAS NO: 99548-54-6
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07056
• Product Categories: Aromatic Esters;Acids & Esters;Bromine Compounds;Aromatics;Miscellaneous Reagents
• Mol File: 99548-54-6.mol
• Article Data: 42

Chemical Properties

• Melting Point: 29 °C
• Boiling Point: 140°C/21mmHg(lit.)
• Flash Point: 108.785 °C
• Appearance: white solid
• Density: 1.434 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform
• CAS DataBase Reference: 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER(99548-54-6)
• EPA Substance Registry System: 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER(99548-54-6)

Safety Data

• Hazardous Substances Data: 99548-54-6(Hazardous Substances Data)

Usage

Uses

3-Bromo-2-methylbenzoic Acid Methyl Ester is a compound useful in organic synthesis.

Chemical Properties

White Solid

Upstream product

• 67-56-1 methanol 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 74-88-4 methyl iodide 
• 118-90-1 ortho-methylbenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 79670-17-0 methyl 2-bromomethyl-5-bromobenzoate 
• 1240216-51-6 C₁₇H₁₃⁽¹⁵⁾NO₄ 
• 102308-43-0 4-bromoisobenzofuran-1(3H)-one 
• 914220-72-7 C₉H₈BrClO₂ 
• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 1361938-20-6 C₁₆H₁₄O₃ 
• 329222-89-1 C₁₅H₁₂O₃ 
• 1329496-87-8 methyl 2-methyl-[1,1’-biphenyl]-3-carboxylate 
• 169045-01-6 7-amino-4-bromoisoindolin-1-one 
• 727381-70-6 dimethyl 2,2’-dimethyl-[1,1’-biphenyl]-3,3’-dicarboxylate 

Relevant articles and documents

Novel biphenyl derivative as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and discloses biphenyl derivatives with PD-1/PD-L1 inhibitory activity as well as a preparation method and application of the biphenyl derivatives. The invention further discloses a composition containing the biphenyl derivative with the PD-1/PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and application of the biphenyl derivative in preparation of a PD-1/PD-L1 inhibitor. The compound can be used for treating tumors.

Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons

A palladium-catalyzed tandem carbonylative lactonization and Diels-Alder cycloaddition reaction between aldehyde-tethered benzylhalides and alkenes has been developed. A range of alkenes and aldehyde-tethered benzylhalides bearing different substituents can be successfully transformed into the corresponding bridged polycyclic compounds in good yields. This strategy provides a unique approach to complex lactone-containing bridged polycyclic compounds.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.