N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

Base Information

Chemical Name:N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine
CAS No.:128563-31-5
Molecular Formula:C₂₉H₃₂BrN₅O₄
Molecular Weight:594.508
Hs Code.:

N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

Synonyms:N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

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Chemical Property of N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

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Technology Process of N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

There total 5 articles about N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid (3aR,4R,6R,6aR)-6-{5-[1-{benzyl-[2-(4-bromo-phenyl)-ethyl]-amino}-eth-(E)-ylideneamino]-4-cyano-imidazol-1-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 128563-31-5
N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

Guidance literature:: With ammonia; In methanol; Yield given;
DOI:10.1139/v92-166

Reference yield:

: 73918-56-6
4-Bromophenethylamine

: 128563-31-5
N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / borane-pyridine complex, acetic acid / petroleum ether / 2 h / Ambient temperature

2: 87 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

3: phosphoryl chloride / acetonitrile / 48 h

4: ammonia / methanol

With borane pyridine; ammonia; acetic acid; triethylamine; trichlorophosphate; In methanol; dichloromethane; acetonitrile; Petroleum ether;
DOI:10.1139/v92-166

Reference yield:

: 100-52-7
benzaldehyde

: 128563-31-5
N-Benzyl-N-[2-(4-bromo-phenyl)-ethyl]-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-acetamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / borane-pyridine complex, acetic acid / petroleum ether / 2 h / Ambient temperature

2: 87 percent / triethylamine / CH₂Cl₂ / 18 h / Ambient temperature

3: phosphoryl chloride / acetonitrile / 48 h

4: ammonia / methanol

With borane pyridine; ammonia; acetic acid; triethylamine; trichlorophosphate; In methanol; dichloromethane; acetonitrile; Petroleum ether;
DOI:10.1139/v92-166