5-Androsten-3β-ol-17-one Methanesulfonate

Base Information

• Chemical Name: 5-Androsten-3β-ol-17-one Methanesulfonate
• CAS No.: 25810-70-2
• Molecular Formula: C₂₀H₃₀O₄S
• Molecular Weight: 366.522
• Mol file: 25810-70-2.mol

Synonyms:androst-5-en-3β-ol-17-one mesylate

Chemical Property of 5-Androsten-3β-ol-17-one Methanesulfonate

Chemical Property:

• Boiling Point: 521.2±50.0 °C(Predicted)
• Density: 1.21±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Androsten-3β-ol-17-one Methanesulfonate is an intermediate in the synthesis of Sodium Prasterone Sulfate (S673250), an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.

Technology Process of 5-Androsten-3β-ol-17-one Methanesulfonate

There total 2 articles about 5-Androsten-3β-ol-17-one Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

dehydroepiandrosterone (53-43-0) + methanesulfonyl chloride (124-63-0) → androst-5-en-3β-ol-17-one mesylate (25810-70-2)

Guidance literature:

With pyridine; at 20 - 25 ℃; for 20h; Inert atmosphere;

Reference yield:

→ 3β-Mesyloxy-5-androsten-17-on (25810-70-2)

Guidance literature:

Methansulphonylchlorid, 3β-Hydroxyandrost-5-en-17-on;

DOI:10.1039/j39700002473

Reference yield:

androst-5-en-3β-ol-17-one mesylate (25810-70-2) → dehydroepiandrosterone (53-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 18-crown-6 ether; 4-methyl-morpholine / 24 h / Reflux; Inert atmosphere

2: sodium hydroxide; methanol / 4 h / 40 °C / Inert atmosphere

3: pyridine / 20 h / 20 - 25 °C / Inert atmosphere

4: 18-crown-6 ether; 4-methyl-morpholine / 24 h / Reflux; Inert atmosphere

5: sodium hydroxide; methanol / 4 h / 40 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; methanol; 18-crown-6 ether; sodium hydroxide;

upstream raw materials:

dehydroepiandrosterone

methanesulfonyl chloride

Downstream raw materials:

prasterone acetate

dehydroepiandrosterone