N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

Base Information

Chemical Name:N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide
CAS No.:1234572-62-3
Molecular Formula:C₂₀H₁₅F₄N₇OS
Molecular Weight:477.445
Hs Code.:

Synonyms:N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

There total 5 articles about N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 41463-83-6
3,3,3-trifluoropropanoyl chloride

: 1234572-51-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidine-4,5,6-triamine

: 1234572-62-3
N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 42h;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1234572-62-3
N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: pyridine / 42 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 66607-27-0
3-iodoindazole

: 1234572-62-3
N-(4,6-Diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: pyridine / 42 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;