Fosifloxuridine nafalbenamide

Base Information

Chemical Name:Fosifloxuridine nafalbenamide
CAS No.:1332837-31-6
Molecular Formula:C₂₉H₂₉FN₃O₉P
Molecular Weight:613.536
Hs Code.:
UNII:4YO6QT3SZ9
Nikkaji Number:J3.616.613D
NCI Thesaurus Code:C156680
Metabolomics Workbench ID:155134
ChEMBL ID:CHEMBL2181367

Synonyms:NUC-3073

Suppliers and Price of Fosifloxuridine nafalbenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Fosifloxuridine nafalbenamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:12
Exact Mass:613.16254467
Heavy Atom Count:43
Complexity:1100

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)OCC1=CC=CC=C1)NP(=O)(OCC2C(CC(O2)N3C=C(C(=O)NC3=O)F)O)OC4=CC=CC5=CC=CC=C54
Isomeric SMILES:C[C@@H](C(=O)OCC1=CC=CC=C1)NP(=O)(OC[C@@H]2[C@H](C[C@@H](O2)N3C=C(C(=O)NC3=O)F)O)OC4=CC=CC5=CC=CC=C54
Recent ClinicalTrials:A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer
Recent EU Clinical Trials:A randomised, open-label, Phase II, dose/schedule optimisation study of NUC-3373/leucovorin/irinotecan plus bevacizumab (NUFIRI-bev) versus 5-FU/leucovorin/irinotecan plus bevacizumab (FOLFIRI-bev) for the treatment of patients with previously treated unresectable metastatic colorectal cancer

Technology Process of Fosifloxuridine nafalbenamide

There total 6 articles about Fosifloxuridine nafalbenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 906670-24-4
1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 1332837-31-6
5'-[1-naphthyloxy-((S)-(1-benzyloxycarbonylethyl)amino)phosphoryl]-5-fluoro-2'-deoxyuridine

: 1332837-32-7
C₂₉H₂₉FN₃O₉P

Guidance literature:: 5-Fluoro-2'-deoxyuridine; With tert-butylmagnesium chloride; In tetrahydrofuran; for 0.5h; Inert atmosphere;

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bcp.2011.05.024

Reference yield: 8.0%

: 906670-24-4
1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 1332837-31-6
5'-[1-naphthyloxy-((S)-(1-benzyloxycarbonylethyl)amino)phosphoryl]-5-fluoro-2'-deoxyuridine

Guidance literature:: 5-Fluoro-2'-deoxyuridine; With 1-methyl-1H-imidazole; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bcp.2011.05.024