Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

• Chemical Name: Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS No.: 81668-74-8
• Molecular Formula: C₁₉H₂₁ClN₂O₉S
• Molecular Weight: 488.903
• Mol file: 81668-74-8.mol

Synonyms:Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property of Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(p-chlorophenylsulfonyl)ethyl chloroformate (112723-64-5) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (81668-74-8)

Guidance literature:

DOI:10.1016/S0040-4039(01)93035-7

Reference yield:

Carbonic acid 2-(4-chloro-benzenesulfonyl)-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (81668-74-8) → p-chlorophenyl vinyl sulfone (5535-51-3) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4)

Guidance literature:

With triethylamine; In pyridine; at 20 ℃; for 5h; relative rates of deprotections of other 4-substituted 2-arylsulfonylethylcarbonate derivatives of thymidine;

DOI:10.1016/S0040-4039(01)93035-7

upstream raw materials:

2-(p-chlorophenylsulfonyl)ethyl chloroformate

thymidine

Downstream raw materials:

p-chlorophenyl vinyl sulfone

thymidine