O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

Base Information

Chemical Name:O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate
CAS No.:130849-54-6
Molecular Formula:C₂₅H₃₄FN₂O₆P
Molecular Weight:508.527
Hs Code.:

Synonyms:O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

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Chemical Property of O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

Chemical Property:

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Technology Process of O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

There total 4 articles about O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

: 1142-20-7
N-benzyloxycarbonyl-L-alanine

: 130848-64-5
O,O-diisopropyl-1-amino-2-(4-fluorophenyl)ethylphosphonate

: 130849-54-6
O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 352-32-9
p-fluorotoluene

: 130849-54-6
O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: NBS / AIBN / CCl₄

2: 1) LDA / 1) THF, - 75 deg C, 1 h,, 2a) 1 h, 2b) overnight, r.t.

3: 83.1 percent / H₂ / Pd/C (5percent Pd) / propan-2-ol / 19 h / 20 - 25 °C

4: 94.4 percent / dicyclohexylcarbodiimid / CH₂Cl₂ / 12 h / 20 °C

With N-Bromosuccinimide; hydrogen; dicyclohexyl-carbodiimide; lithium diisopropyl amide; 2,2'-azobis(isobutyronitrile); 5%-palladium/activated carbon; In tetrachloromethane; dichloromethane; isopropyl alcohol;

Reference yield:

: 130828-86-3
O,O-diisopropyl-1-N-benzylidenamino-2-(4-fluorophenyl)ethylphosphonate

: 130849-54-6
O,O-diisopropyl-1-N-(Z-L-alanylamino)-2-(4-fluorophenyl)-ethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 83.1 percent / H₂ / Pd/C (5percent Pd) / propan-2-ol / 19 h / 20 - 25 °C

2: 94.4 percent / dicyclohexylcarbodiimid / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; dicyclohexyl-carbodiimide; 5%-palladium/activated carbon; In dichloromethane; isopropyl alcohol;