(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Base Information

Chemical Name:(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol
CAS No.:155638-30-5
Molecular Formula:C₁₄H₂₄O₃
Molecular Weight:240.343
Hs Code.:

Synonyms:(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

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Chemical Property of (+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

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Technology Process of (+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

There total 8 articles about (+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 155638-29-2
(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol-tetrahydropyranyl ether

: 155638-30-5
(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 55 ℃; for 6.5h;

Reference yield:

: 2816-57-1
2,6-dimethylcyclohexanone

: 155638-30-5
(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) diisopropylamine, n-BuLi / 1) THF, hexane, -75 deg C; 2) THF, hexane, -25 --> -15 deg C, 60 min

2: 95 percent / pyridine / 21 h / Ambient temperature

3: 79 g / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

4: 39 percent / aq. NaOH / 1 h / Ambient temperature

5: 92 percent / NaH / tetrahydrofuran / 16 h / Ambient temperature

6: 97 percent / HCl / methanol / 39 h / Ambient temperature

7: 1.) n-BuLi / 1) THF, hexane, -75 deg C, 1 h; 2) THF, hexane, 2 h, -25 --> -10 deg C

8: 86 percent / pyridinium p-toluenesulfonate / ethanol / 6.5 h / 55 °C

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; methanol; ethanol; benzene;

Reference yield:

: 13756-98-4
(+/-)-2-hydroxymethyl-2,6-dimethyl-1-cyclohexanone

: 155638-30-5
(+/-)-4-(1'-hydroxy-2'-methoxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / pyridine / 21 h / Ambient temperature

2: 79 g / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

3: 39 percent / aq. NaOH / 1 h / Ambient temperature

4: 92 percent / NaH / tetrahydrofuran / 16 h / Ambient temperature

5: 97 percent / HCl / methanol / 39 h / Ambient temperature

6: 1.) n-BuLi / 1) THF, hexane, -75 deg C, 1 h; 2) THF, hexane, 2 h, -25 --> -10 deg C

7: 86 percent / pyridinium p-toluenesulfonate / ethanol / 6.5 h / 55 °C

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; benzene;