(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Base Information

Chemical Name:(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid
CAS No.:1462267-54-4
Molecular Formula:C₂₀H₂₂O₆S
Molecular Weight:390.457
Hs Code.:

Synonyms:(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

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Technology Process of (E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

There total 5 articles about (E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 3-methoxy-2-(methylthio)benzaldehyde

: 1462267-54-4
(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Guidance literature:: With acetic anhydride; trimethylamine; at 115 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.11.050

Reference yield:

: 88791-03-1
O-(2-formyl-6-methoxyphenyl)-N,N-dimethylthiocarbamate

: 1462267-54-4
(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diphenylether / 0.5 h / 240 °C / Inert atmosphere

2: potassium hydroxide / methanol / 2.5 h / 80 °C / Inert atmosphere

3: methanol / 20 h / 20 °C / Inert atmosphere

4: acetic anhydride; trimethylamine / 4 h / 115 °C / Inert atmosphere

With acetic anhydride; potassium hydroxide; trimethylamine; In methanol; diphenylether; 1: |Newman-Kwart Rearrangement;
DOI:10.1016/j.ejmech.2017.11.050

Reference yield:

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 1462267-54-4
(E)-3-(3-methoxy-2-methylthiophenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / water; tetrahydrofuran / 0.83 h / 0 - 20 °C

2: diphenylether / 0.5 h / 240 °C / Inert atmosphere

3: potassium hydroxide / methanol / 2.5 h / 80 °C / Inert atmosphere

4: methanol / 20 h / 20 °C / Inert atmosphere

5: acetic anhydride; trimethylamine / 4 h / 115 °C / Inert atmosphere

With acetic anhydride; potassium hydroxide; trimethylamine; In tetrahydrofuran; methanol; diphenylether; water; 2: |Newman-Kwart Rearrangement;
DOI:10.1016/j.ejmech.2017.11.050