4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide
CAS No.:1232234-11-5
Molecular Formula:C₂₅H₂₆ClN₅O₂S
Molecular Weight:496.033
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

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Chemical Property of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

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Technology Process of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

There total 15 articles about 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232234-96-6
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

: 1232234-11-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1232234-37-5
4-dimethoxymethyl-2-fluoro-1-nitro-benzene

: 1232234-11-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrogenchloride; water / acetonitrile / 0.5 h / 60 °C

3.1: ammonium chloride; zinc / tetrahydrofuran / 1 h

4.1: acetic acid / 1 h

4.2: pH 9

5.1: phenyllithium / tetrahydrofuran / -78 °C

5.2: 20 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

7.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

9.1: potassium carbonate / acetonitrile / 6 h / Reflux

10.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

10.2: pH ~ 6 - 7

11.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; boron dimethyl-trifluoro sulphide; water; hydrogen; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; phenyllithium; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; zinc; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1H-1,3-benzodiazole-6-carbaldehyde

: 1232234-11-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 1 h / 20 °C

2.1: phenyllithium / tetrahydrofuran / -78 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

4.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 6 h / Reflux

7.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

7.2: pH ~ 6 - 7

8.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With boron dimethyl-trifluoro sulphide; water; hydrogen; sodium hydride; potassium carbonate; ammonium chloride; phenyllithium; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;