4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid
CAS No.:1232234-96-6
Molecular Formula:C₂₅H₂₅ClN₄O₃S
Molecular Weight:497.018
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

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Chemical Property of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

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Technology Process of 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

There total 14 articles about 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232234-95-5
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

: 1232234-96-6
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

Guidance literature:: 4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=~ 6 - 7;

Reference yield:

: 1232234-37-5
4-dimethoxymethyl-2-fluoro-1-nitro-benzene

: 1232234-96-6
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrogenchloride; water / acetonitrile / 0.5 h / 60 °C

3.1: ammonium chloride; zinc / tetrahydrofuran / 1 h

4.1: acetic acid / 1 h

4.2: pH 9

5.1: phenyllithium / tetrahydrofuran / -78 °C

5.2: 20 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

7.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

9.1: potassium carbonate / acetonitrile / 6 h / Reflux

10.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

10.2: pH ~ 6 - 7

With hydrogenchloride; boron dimethyl-trifluoro sulphide; water; hydrogen; potassium carbonate; ammonium chloride; caesium carbonate; acetic acid; phenyllithium; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1H-1,3-benzodiazole-6-carbaldehyde

: 1232234-96-6
4-(3-chloro-phenyl)-2-[6-(4-morpholin-4-yl-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 1 h / 20 °C

2.1: phenyllithium / tetrahydrofuran / -78 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

4.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 6 h / Reflux

7.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

7.2: pH ~ 6 - 7

With boron dimethyl-trifluoro sulphide; water; hydrogen; sodium hydride; potassium carbonate; phenyllithium; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;