Multi-step reaction with 5 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 16 h / Reflux
2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate / 4 h / 65 °C
3: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C
4: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C
5: hydrogenchloride / water; methanol / 3 h / 20 °C
With
hydrogenchloride; lithium hydroxide monohydrate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;