Technology Process of EPZ006088
There total 13 articles about EPZ006088 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 100 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / acetonitrile / 7 h / 80 °C
2.1: sodium hydroxide; water / methanol / 1 h / 60 °C
2.2: pH 6
2.3: pH 4
3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; caesium carbonate; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water; dimethyl sulfoxide; acetonitrile;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / methanol / 1 h / 60 °C
1.2: pH 6
1.3: pH 4
2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; water; dimethyl sulfoxide;
3.1: Suzuki Coupling;
