5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Base Information

Chemical Name:5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide
CAS No.:1403257-15-7
Molecular Formula:C₂₂H₂₈BrN₃O₂
Molecular Weight:446.387
Hs Code.:

Synonyms:5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

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Chemical Property of 5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

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Technology Process of 5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

There total 10 articles about 5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403257-16-8
C₁₄H₁₈BrNO₂

: 1403257-15-7
5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: C₁₄H₁₈BrNO₂; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; In dimethyl sulfoxide; Product distribution / selectivity;

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403257-15-7
5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 2 h / 20 °C

1.2: 16 h / 20 °C

2.1: caesium carbonate / acetonitrile / 12 h / 80 °C

3.1: sodium hydroxide; water / ethanol / 4 h / 60 °C

3.2: pH 4 - 6

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1403257-13-5
methyl 5-bromo-3-(cyclopentylamino)-2-methylbenzoate

: 1403257-15-7
5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / acetonitrile / 12 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 4 h / 60 °C

2.2: pH 4 - 6

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; sodium hydroxide; In ethanol; dimethyl sulfoxide; acetonitrile;