Technology Process of 5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide
There total 10 articles about 5-bromo-3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C14H18BrNO2;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.25h;
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one;
In
dimethyl sulfoxide;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / methanol / 2 h / 20 °C
1.2: 16 h / 20 °C
2.1: caesium carbonate / acetonitrile / 12 h / 80 °C
3.1: sodium hydroxide; water / ethanol / 4 h / 60 °C
3.2: pH 4 - 6
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; acetic acid; sodium hydroxide;
In
methanol; ethanol; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / acetonitrile / 12 h / 80 °C
2.1: sodium hydroxide; water / ethanol / 4 h / 60 °C
2.2: pH 4 - 6
3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 0.25 h / 20 °C
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; sodium hydroxide;
In
ethanol; dimethyl sulfoxide; acetonitrile;
